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Breast Cancer Cell lines
Through licensing agreements with the University of Michigan and the Karmanos Cancer Institute, Asterand provides 11 well characterized human breast cancer cell lines to assist in breast cancer research.
Ten SUM cell lines derived in Steve Ethier’s lab while present at the University of Michigan are available for purchase. Each cell line, from a single patient, represents a different subtype of breast cancer. All of the currently known oncogenes with altered expression patterns in breast cancer, in various combinations, are represented and characterized in the SUM lines. These cell lines have been described in over 50 peer-reviewed publications, describing isolation and growth conditions, gene expression data through the use of Affymetrix GeneChips, and biomolecular markers, such as estrogen receptor and Her2 status. Click here to see a bibliography.
Asterand also offers the human breast cell line MCF10DCIS.com to researchers looking to model early breast cancer. MCF10DCIS.com is a clonal breast cancer cell line, derived by researchers in the Barbara Ann Karmanos Cancer Institute at Wayne State University. Pre-malignant MCF10AT cells were injected into severe combined immunodeficient (SCID) mice, resulting in tumor growth. The DCIS.com line was cloned from cell culture of this xenograft. Click here to see a bibliography.
All cell lines are provided in cryovial of ~1x106 cells. All of the cell lines available from Asterand were developed in conjunction with different academic institutions. As a result of our agreements with these institutions, we offer our cell lines to academic and governmental researchers at prices lower than those available to our commercial customers. If you have any questions about this policy, please email us at advantage@asterand.com.
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