Home > Human Gene Profiles >

ACVR2B XpressWay Gene Expression Profile

 
US Price: $2,000.00

Stock Status:In Stock

Description
 
ACVR2B Xpressway Gene Expression Profile

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
ACVR2B

Swiss Description: Activin receptor type-2B; Activin receptor type IIB

N_Accession: NM_001106
P_accession: Q13705

With Asterand’s TargetEvaluator® database consisting of more than 2000 XpressWay® Gene Expression Profiles, you are sure to find a target of interest. XpressWay® Profiles consist of high quality target expression in 72 normal human tissues from 3 different donors. The tissues are chosen to be representative of the major organ systems of the human body, and comprise many sub-dissected regions. Total RNA is isolated from tissues using Asterand’s standard methodologies, and gene expression is measured using highly sensitive and quantitative real time-PCR. Target gene transcripts are multiplexed with GAPDH as a control for the PCR process. Each XpressWay Sample Report presents visual expression profiles and a complete data set for your gene of interest. Click here for full details of Asterand's qRT-PCR methodologies used to generate XpressWay Profiles.

Profiles are purchased with a license and you will be provided in a full profile report. While any number of profiles may be purchased, if you are purchasing more than 20 profiles, please contact advantage@asterand.com so that your Regional Business Development Director may contact you for special tiered pricing.